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A Real-World Perspective on Molecular Design——————Miniperspective
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland
journal of medicinal chemistry, in press
DPP-IV Filling a lipophilic pocket Affinity increase while balancing polarity
FABP 4/5 Targeting specific residue differences in the binding site Affinity and selectivity increase
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