SGLT2 抑制剂类糖尿病药物研发现状
尽管上个专题的帖子,没过10不过有不少朋友关注,继续更新一期,绝对对是精品,哈哈。SGLT2 抑制剂类糖尿病药物研发现状
钠-葡萄糖共转运蛋白 2 (SGLT-2) 抑制剂是相对较新的一类口服降糖药。葡萄糖易化转运体 (GLUT)与SGLT 是人体内参与葡萄糖吸收和重吸收转运体的两大家族。其中SGLT 家族中代表性的成员是SGLT-1 和SGLT-2。SGLT-1 主要分布在小肠、肾脏、心脏和脑内,其主要生理功能为在小肠完成对葡萄糖的吸收。SGLT-2 特异性的分布在肾脏近曲小管S1 部位,负责约 90%葡萄糖的重吸收,剩余10%由位于近曲小管S3 部位的SGLT-1 完成。SGLT2 抑制剂通过特异性地阻断肾脏对葡萄糖的重吸收,通过尿排出多余的葡萄糖,从而有效地降低糖尿病患者血糖水平。
在研药物现状
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
根据Thomson Reuters Cortellis 的统计,目前已上市和在研的SGLT2 抑制剂类糖尿病药物共有24 个(包括联合用药,另有11 个药物未见进一步的报道或已撤回),其中已上市的药物是三菱田边和强生公司共同开发的canagliflozin(2013年3 月获得FDA 批准)和百时美施贵宝公司与阿斯利康公司共同开发的dapagliflozin(2012 年在欧洲获批,目前已在英国、德国和丹麦国上市,2012 年1 月由于可能的膀胱癌和乳腺癌风险,FDA 拒绝了该药物的上市请求)。在研的SGLT2 抑制剂目前最高的研发状态参见图。
data:image/png;base64,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
SGLT2 抑制剂类糖尿病药物最高研究状态分布
(数据来源:Thomson Reuters Cortellis 检索日期:2013-07-10)
目前在SGLT2 抑制剂领域研发较为活跃的公司是辉瑞、勃林格殷格翰、默沙东、百时美施贵宝和阿斯利康,这几家公司目前均有3 个在研的SGLT2 抑制剂,强生公司则拥有两个,其余如赛诺菲、诺华、安斯泰来等多家公司目前拥有1 个SGLT2 抑制剂在研药物。
简要评述
尽管在2012 年, dapagliflozin 在美国上市受挫没,但是有报道称百时美施贵宝正与FDA 保持沟通,计划今年内再度提交上市申请。如果顺利的话,勃林格殷格翰与礼来公司共同开发的empagliflozin 也会在短期内在美国和欧洲上市。另一个值得关注的SGLT-2 抑制剂是默沙东和辉瑞公司共同开发的ertugliflozin,它单独治疗的方案将会在今年晚些时候进入Ⅲ期临床。
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
作为相对新颖的作用机制的糖尿病治疗药物,SGLT-2 抑制剂在临床上表现出一些令人意想不到的积极的和负面的效应,主要包括降低体重、增加尿路感染的风险、降低血压、增加脱水症的风险以及高钾血症等。正是这些意外的正面或负面的效应将在很大程度上影响SGLT-2 抑制剂的上市和销售前景。例如,考虑到糖尿病人很多面临着肥胖的问题,尤其是注射胰岛素导致进食增加,SGLT-2
抑制剂能在很大程度上抵消由此导致体重增加。但是尿路感染、对血压的影响等负作用增加了医生和患者使用SGLT-2 抑制剂的疑虑。目前,糖尿病发病率不断攀升。尤其是考虑到糖尿病是一种渐进性疾病,患者在长期用药的过程中有淘汰老药换用新型药物的需求,新的作用机制的药物往往会具有很大的市场前景。SGLT-2 抑制剂也不例外。百时美施贵宝的发言人指出,尽管市场上有多种作用机制的许多糖尿病药物,但是目前许多2 型糖尿病患者很难达到或维持糖化血红蛋白指标,这样巨大的未被满足的医疗需求为新作用机制的糖尿病药物提供了巨大市场需求。因此,可以认为SGLT-2 抑制剂是很有市场前景的一类糖尿病药物。但是由于作用机制较为新颖,大规模临床数据相对较少,在开发此类药物时,应当密切关注目前在研药物临床进展以及已上市药物的上市后研究。
楼主能不能再给推荐几个好点的网站啊,我每次看到你能找那么多好的东西都眼馋啊,可惜新手完全不知道怎么查:( apple 发表于 2013-8-2 09:52 static/image/common/back.gif
楼主能不能再给推荐几个好点的网站啊,我每次看到你能找那么多好的东西都眼馋啊,可惜新手完全不知道怎么查 ...
呵呵 ,不好意思哈,确实没什么好的网站,我的找的我们单位的内部期刊。 楼主是不是从事糖尿病相关研究的啊?
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