论坛 › 【新药研发】 › 基于片段化药物设计新进展 (JMC)

dejunchem 发表于 2013-4-6 15:32:16

基于片段化药物设计新进展 (JMC)

本帖最后由 dejunchem 于 2013-4-6 15:34 编辑

De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation

dejunchem 发表于 2013-4-6 15:34:01

这一篇就不跟大家做翻译了，有兴趣的可以看看~

The use of fragments with low binding affinity for their targets as starting points has received much attention recently. Screening of fragment libraries has been the most common method to find attractive starting points. Herein, we describe a unique, alternative approach to generating fragment leads. A binding model was developed and a set of guidelines were then selected to use this model to design fragments, enabling our discovery of a novel fragment with high LE.

xufund 发表于 2013-4-6 18:37:16

谢谢分享啊

dejunchem 发表于 2013-4-7 09:59:20

感谢支持！

川大-灰太狼 发表于 2013-4-7 11:39:22

哈哈 丁丁 谢谢分享！非常实用

枫叶飘飞 发表于 2013-6-5 11:14:13

谢谢分享！非常实用

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