dejunchem 发表于 2013-3-31 12:59:55

计算药物重新定位：从数据到药物


计算药物重新定位：从数据到药物
Computational Drug Repositioning: From Data to Therapeutics


         Traditionally, most drugs have been discovered using phenotypic or target-based screens. Subsequently, their indications are often expanded on the basis of clinical observations, providing additional benefit to patients. This review highlights computational techniques for systematic analysis of transcriptomics (Connectivity Map, CMap), side effects, and genetics (genome-wide association study, GWAS) data to generate new hypotheses for additional indications. We also discuss data domains such as electronic health records (EHRs) and phenotypic screening that we consider promising for novel computational repositioning methods.

       计算机辅助的药物设计改何去何从,客官们,请看此处综述！

nature publishing group
Clinical Pharmacology & Therapeutics, 2013, 93(4): 335–341

dejunchem 发表于 2013-3-31 13:01:17

沙发有奖励噢~~

xxffliu 发表于 2013-4-1 06:20:18

表型筛选，毒副作用指纹和GWCS三足鼎立啊，分子模拟技术在重定向和新靶标识别方面越来越小众了……

北京-构效 发表于 2013-9-16 10:09:00

篇篇是精品啊

ts2009 发表于 2013-9-16 12:39:46

好东西顶一个

/rose水水 发表于 2014-1-16 09:47:05

下下来慢慢看！

princcer 发表于 2014-3-22 20:24:54

i use one of my only three golden coins to buy your paper.
页: [1]
查看完整版本: 计算药物重新定位：从数据到药物